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Bio-Techne corporation
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Rockland Immunochemicals
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St Johns Laboratory
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Revvity
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Boster Bio
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Becton Dickinson
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GeneTex
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MBL International
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Its translation stimulation activity is repressed by binding to the complex CYFIP1-FMR1 (By similarity). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding
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Image Search Results
Journal: Cancer biology & therapy
Article Title: Inhibition of cytosolic phospholipase A2 alpha increases chemosensitivity in cervical carcinoma through suppressing β-catenin signaling.
doi: 10.1080/15384047.2019.1579961
Figure Lengend Snippet: Figure 7. cPLA2α inhibition suppresses Akt/eIF4E/β-catenin signaling in cervical cells. cPLA2α inhibition by inhibitors (a) or siRNA (b) significantly decreases cPLA2α enzyme activity in cervical cancer cells. cPLA2α inhibition by inhibitors (c) or siRNA (d) decreases βAkt (Ser473), p-eIF4E (Ser209), and β-catenin in CaLo cells. (e) Pyrrophenone and RSC-3388 at 100 nM significantly inhibit TOPflash activation. CaLo cells transfected with TOPflash plasmid were treated as indicated. The graph represents mean ± s.e.m. of TOPflash signal relative to control. cPLA2α inhibitors (f) and siRNA (g) significantly decrease the transcript level of C-MYC, BCL9, and CYCLIN D genes in CaLo cells. *p < 0.05 compared to control or siRNA con (scrambled siRNA).
Article Snippet: Antibodies for cPLAα, p-Akt, Akt, p-eIF4E,
Techniques: Inhibition, Activity Assay, Activation Assay, Transfection, Plasmid Preparation, Control